I wouldn't say "all the time", but it has been done before and there are a few guys here that run a v8. Some love it and have no regrets, others would never ever do it again, and others never get all the bugs worked out and eventually just sell off the truck to get rid of it. Be prepared to kiss your drivetrain goodbye. Be prepared to fight to keep the beast cool. And be prepared to either fabricate your own brackets, mounts etc. or pay out the butt to advanceadapters.com for the parts you need. It is not for the feint of heart.